Overview of bioinformatics, Scope of bioinformatics & its applications of bioinformatics; Introduction to databases: Bibliographic and Sequences databases, tools for performing sequence analysis and literature searches. Assessment of biological data and analytical tool via computers; Bioinformatics utilities and web-based resources; GCG and Entrez. Data bases; genome, sequence and mutation data bases: PCR primer and probe design data bases; clone catalogues; sequence comparison facilities. Design of synthetic genes encoding for specific structural proteins. Design and synthesis of new generation of advanced structural materials: analogues of biopolymers. mathematical and algorithmic models of sequence analysis and alignments, Software facilities; linkage analysis, primer design and selection and other molecular data softwares. Computer generated models of special protein structures.